ATIC-IN-1

• Description:

  ATIC-IN-1 (compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1].

• UNSPSC:

  12352005

• Target:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/atic-in-1.html

• Purity:

  99.69

• Solubility:

  10 mM in DMSO

• Smiles:

  N=C(N)NCCC[C@H](NC(C)=O)C(N[C@H](C(N(CC)CC)=O)CC1=CC=C(C=C1)[N+]([O-])=O)=O

• Molecular Formula:

  C21H33N7O5

• Molecular Weight:

  463.53

• References & Citations:

  [1]Spurr IB, et al. Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization. Chembiochem. 2012 Jul 23;13 (11) :1628-34.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1402453-15-9]