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ATIC-IN-1

CAT: 0804-HY-150252Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150252Size:1 Each
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Description
ATIC-IN-1 (compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1].
CAS Number
1402453-15-9
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atic-in-1.html
Purity
99.69
Solubility
10 mM in DMSO
Smiles
N=C(N)NCCC[C@H](NC(C)=O)C(N[C@H](C(N(CC)CC)=O)CC1=CC=C(C=C1)[N+]([O-])=O)=O
Molecular Formula
C21H33N7O5
Molecular Weight
463.53
References & Citations
[1]Spurr IB, et al. Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization. Chembiochem. 2012 Jul 23;13 (11) :1628-34.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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