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GSK3739936

CAT: 0804-HY-150080Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150080Size:1 Each
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Description
GSK3739936 (BMS-986180) is a potent HIV-1 allosteric integrase inhibitor with an IC50 value of 11.1 nM and an EC50 value of 1.7 nM. GSK3739936 is also a weak CYP inhibitor (IC50>24.3 μM) . GSK3739936 shows favorable pharmacokinetic property in preclinical species with rapid absorption, low to moderate clearance and excellent oral bioavailability[1].
CAS Number
1803444-21-4
Product Name Alternative
BMS-986180
UNSPSC
12352005
Target
HIV; HIV Integrase
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gsk3739936.html
Solubility
10 mM in DMSO
Smiles
CC1=NC(C)=C(C(N2CCC(C)(CC2)C)=C1[C@@H](C(O)=O)OC(C)(C)C)C3=CC=C(C=C3)OCCC4=CC=C(C=C4)F
Molecular Formula
C34H43FN2O4
Molecular Weight
562.71
References & Citations
[1]Naidu BN, et al. Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs. J Med Chem. 2022 Mar 24;65 (6) :4949-4971.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1

Alternative Products

CatalogName
T63977-01GSK3739936

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