ICMT-IN-53

• UNSPSC Description:

  ICMT-IN-53 (compound 12) is an ICMT inhibitor (IC50=0.96 μM) with PAMPA permeability and antiproliferative activity. ICMT-IN-53 inhibits the proliferation of MDA-MB-231 and PC3 with IC50s of 5.14 μM and 5.88 μM, respectively[1].

• Target Antigen:

  ICMT

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/icmt-in-53.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=C(C=CN=C1)C2=CC=C(N(CCCCCCCC)C=C3CN(CC)CC)C3=C2

• Molecular Weight:

  409.58

• References & Citations:

  [1]Ramanujulu PM, et al. Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). Eur J Med Chem. 2013 May;63:378-86.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1443253-17-5