ICMT-IN-53

ICMT-IN-53

• CAS Number: 1443253-17-5
• UNSPSC Description: ICMT-IN-53 (compound 12) is an ICMT inhibitor (IC50=0.96 μM) with PAMPA permeability and antiproliferative activity. ICMT-IN-53 inhibits the proliferation of MDA-MB-231 and PC3 with IC50s of 5.14 μM and 5.88 μM, respectively[1].
• Target Antigen: ICMT
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/icmt-in-53.html
• Solubility: 10 mM in DMSO
• Smiles: FC1=C(C=CN=C1)C2=CC=C(N(CCCCCCCC)C=C3CN(CC)CC)C3=C2
• Molecular Weight: 409.58
• References & Citations: [1]Ramanujulu PM, et al. Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). Eur J Med Chem. 2013 May;63:378-86.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported