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ICMT-IN-53

CAT: 0804-HY-149729Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149729Size:1 Each
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Description
ICMT-IN-53 (compound 12) is an ICMT inhibitor (IC50=0.96 μM) with PAMPA permeability and antiproliferative activity. ICMT-IN-53 inhibits the proliferation of MDA-MB-231 and PC3 with IC50s of 5.14 μM and 5.88 μM, respectively[1].
CAS Number
1443253-17-5
UNSPSC
12352005
Target
ICMT
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/icmt-in-53.html
Solubility
10 mM in DMSO
Smiles
FC1=C(C=CN=C1)C2=CC=C(N(CCCCCCCC)C=C3CN(CC)CC)C3=C2
Molecular Formula
C26H36FN3
Molecular Weight
409.58
References & Citations
[1]Ramanujulu PM, et al. Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt) . Eur J Med Chem. 2013 May;63:378-86.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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