DNA Gyrase-IN-9

• UNSPSC Description:

  DNA Gyrase-IN-9 (compound 4j) is an antibacterial agent that targets DNA gyrase. The MIC to inhibit Gram bacteria is 0.5-2 μg/mL, and the MBC to kill Gram bacteria is 2-8 μg/mL. DNA Gyrase-IN-9 inhibits DNA gyrase in Staphylococcus aureus with IC50=6.29 μg/mL[1].

• Target Antigen:

  Bacterial; DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/dna-gyrase-in-9.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CC(C1C2=CC=C(C3=CC=CC=C3)C=C2)=C(O)OC4=C1C(C)=NN4C5=CC=C(Cl)C=C5

• Molecular Weight:

  439.89

• References & Citations:

  [1]Almaghrabi M, et al. Introducing of novel class of pyrano [2, 3-c] pyrazole-5-carbonitrile analogs with potent antimicrobial activity, DNA gyrase inhibition, and prominent pharmacokinetic and CNS toxicity profiles supported by molecular dynamic simulation[J]. Journal of Biomolecular Structure and Dynamics, 2023: 1-18.. . .

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported