DNA Gyrase-IN-2

DNA Gyrase-IN-2

• CAS Number: 2522666-80-2
• UNSPSC Description: DNA Gyrase-IN-2 (Compound 22a) is a bacterial DNA gyrase B inhibitor with IC50s of 3.29-10.49 and 4.41-5.61 µM for E. coli DNA gyrase and M. tuberculosis DNA gyrase. Anti-tubercular and antibacterial activity[1].
• Target Antigen: Bacterial; DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Anti-infection;Cell Cycle/DNA Damage
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/dna-gyrase-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N=C(N/N=C2N=C(N/N=C3CCCCC4=CC=CC=C4/3)SC\2)S/C1=N\NC5=CC=C(C)C=C5
• Molecular Weight: 504.63
• References & Citations: [1]Mohamed A Omar, et al. Novel anti-tubercular and antibacterial based benzosuberone-thiazole moieties: Synthesis, molecular docking analysis, DNA gyrase supercoiling and ATPase activity. Bioorg Chem. 2020 Nov;104:104316.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported