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JNK2-IN-1

CAT: 0804-HY-149485Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149485Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNK2-IN-1 (Compound J27) is a JNK2 inhibitor (Kds: 79.2 μM) . JNK2-IN-1 has anti-inflammatory activity. JNK2-IN-1 decreases the release of TNF-α and IL-6 through inhibiting the activation of NF-κB/MAPK pathway. JNK2-IN-1 alleviates the symptoms of LPS-induced acute lung injury (ALI) and sepsis[1].
CAS Number
2998941-15-2
UNSPSC
12352005
Target
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jnk2-in-1.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C=C1)N2C(C=C(C(C(NC3=CC=C(OC4=C5C(C=C(C(OC)=C5)OC)=NC=C4)C=C3)=O)=N2)C)=O
Molecular Formula
C30H26N4O5
Molecular Weight
522.55
References & Citations
[1]Liao J, et al. Discovery of the Diphenyl 6-Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the JNK2-NF-B/MAPK Pathway. J Med Chem. 2023 Aug 29.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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