SIRT5 inhibitor 7
CAT:
804-HY-149426
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
SIRT5 inhibitor 7
- CAS Number: 2951090-00-7
- UNSPSC Description: SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury[1].
- Target Antigen: Sirtuin
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Epigenetics
- Applications: COVID-19-anti-virus
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/sirt5-inhibitor-7.html
- Solubility: 10 mM in DMSO
- Smiles: S=C(NCCCNC1=NC(NC2=C(Cl)C=CC=C2)=NC=C1C(N3C[C@@H](C4=CC=CC=C4)CC3)=O)NCCC(O)=O
- Molecular Weight: 582.12
- References & Citations: [1]Mou L, et al. Structure-Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury. J Med Chem. 2023 Aug 24;66(16):11517-11535..
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported