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MTase-IN-1

CAT: 0804-HY-149362Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149362Size:1 Each
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Description
MTase-IN-1 (compound 26) is a potent and selective inhibitor of coronavirus nsp14 N7-methyltransferases, with an IC50 of 0.72 nM. MTase-IN-1 impairs viral RNA translation and immune evasion[1].
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mtase-in-1.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)C3C(C#CC4=CN=C(C=CC=C5)C5=C4)=C2)O[C@@H]1CN(S(C6=CC=C(OC)C(C#N)=C6)(=O)=O)C
Molecular Formula
C31H29N7O6S
Molecular Weight
627.67
References & Citations
[1]Hausdorff M, et, al. Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases. Eur J Med Chem. 2023 Aug 5;256:115474.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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