PD07

CAT: 0804-HY-149340Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-149340Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

PD07 is an orally active AChE inhibitor (IC50: 0.29 μM for hAChE). PD07 also inhibits ChEs, BACE1 (IC50: 13.42 μM), and Aβ1–42 aggregation in in vitro. PD07 is an antioxidant, and shows DPPH inhibitory activity (IC50: 26.46 μM). PD07 improves memory and cognition in Scopolamine -induced amnesia rats. PD07 can be used for research of Alzheimer’s disease[1].

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pd07.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(C(N2CCN(C(/C=C/C=C/C3=CC(OCO4)=C4C=C3)=O)CC2)=O)C=C1

Molecular Formula

C23H21ClN2O4

Molecular Weight

424.88

References & Citations

[1]Bhanukiran K, et al. Discovery of Multitarget-Directed Ligands from Piperidine Alkaloid Piperine as a Cap Group for the Management of Alzheimer's Disease. ACS Chem Neurosci. 2023 Aug 2;14 (15) :2743-2760.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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