MKA031

CAT: 0804-HY-149308-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

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CAT#:0804-HY-149308-02Size:10 mM - 1 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MKA031 (compound 6y) is a non-competitive MIF inhibitor with an IC50 value of 1.7 μM. MKA031 (compound 6y) interferes with MIF/AIF interaction, MIF nuclear translocation, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) -induced dependent cell death. MKA031 can be used in the study of chronic hepatitis C virus infection[1].

CAS Number

2951012-00-1

UNSPSC

12352005

Target

Macrophage migration inhibitory factor (MIF)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mka031.html

Purity

98.69

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC=CC=C1)C2=CC=C(C=C2)N3N=NC(C(NCC4=CC=CS4)=O)=C3

Molecular Formula

C21H17N5O2S

Molecular Weight

403.46

References & Citations

[1]Chen D, et al. Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos. J Med Chem. 2023 Jul 13;66 (13) :8767-8781.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

1-[4-(phenylcarbamoyl)phenyl]-N-(thiophen-2-ylmethyl)triazole-4-carboxamide

CAS Number	2951012-00-1
PubChem CID	168475855
IUPAC Name	1-[4-(phenylcarbamoyl)phenyl]-N-(thiophen-2-ylmethyl)triazole-4-carboxamide
Molecular Formula	C21H17N5O2S
Molecular Weight	403.5
XLogP	3
Topological Polar Surface Area	117
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Heavy Atom Count	29
Formal Charge	0
Complexity	563

SMILES

C1=CC=C(C=C1)NC(=O)C2=CC=C(C=C2)N3C=C(N=N3)C(=O)NCC4=CC=CS4

InChI

InChI=1S/C21H17N5O2S/c27-20(23-16-5-2-1-3-6-16)15-8-10-17(11-9-15)26-14-19(24-25-26)21(28)22-13-18-7-4-12-29-18/h1-12,14H,13H2,(H,22,28)(H,23,27)

InChIKey

WHIYNFCIAFTBMZ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2951012-00-1

CID: 168475855

Formula: C21H17N5O2S

MW: 403.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	403.5
XLogP3	3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	403.11029598
Monoisotopic Mass	403.11029598
Topological Polar Surface Area	117 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	563
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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MBS5820378	MKA031

MKA031

Chemical Information

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