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MR22

CAT: 0804-HY-149075-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-149075-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells[1].
CAS Number
3027761-24-3
UNSPSC
12352005
Target
Salt-inducible Kinase (SIK)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mr22.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CNC1=NC=C2C=C(C(N(C2=N1)CCCCN)=O)C3=C(C=CC(F)=C3)F
Molecular Formula
C18H19F2N5O
Molecular Weight
359.37
References & Citations
[1]Marcel Rak, et al. Shifting the selectivity of pyrido[2,3-d]pyrimidin-7 (8H) -one inhibitors towards the salt-inducible kinase (SIK) subfamily. European Journal of Medicinal Chemistry. Volume 254, 5 June 2023, 115347.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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