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MR24

CAT: 0804-HY-157932Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157932Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MR24, a G-5555 derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 shows selectively to MST3/4 over MST1/2, with EC50 values of 57 and 583 nM, respectively. MR24 induces G1 phase cell cycle arrest. MR24 can be used for cancer research, such as breast, liver and lung cancers[1].
CAS Number
3056814-89-9
UNSPSC
12352005
Target
Hippo (MST)
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mr24.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=CC(C2=CC(Cl)=C(C=C2)C3=CC4=C(N(C3=O)CCCCN)N=C(N=C4)NC(CO)CO)=N1
Molecular Formula
C26H29ClN6O3
Molecular Weight
509.00
References & Citations
[1]Marcel Rak, et al. Development of Selective Pyrido[2,3-d]pyrimidin-7 (8H) -one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. J. Med. Chem. 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MST3; MST4

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