Cavα2δ1&NET-IN-3

• UNSPSC Description:

  Cavα2δ1&NET-IN-3 (example 216) is an inhibitor of the subunit α2δ of voltage-gated calcium channels (VGCC) and noradrenaline transporter (NET). Cavα2δ1&NET-IN-3 has Kis of 100-500 nM for human α2δ-1 subunit of Cav2.2 calcium channel and NET, respectively[1].

• Target Antigen:

  Calcium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/cavα2δ1-net-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=CN=C(NCC)N=C2N(CCN1C3=CC(O[C@H](C4=CC=CS4)CCNC)=CC=C3)C

• Molecular Weight:

  466.60

• References & Citations:

  [1]Félix CUEVAS-CORDOBÉS, et al. Tetrahydropyrimidodiazepine and tetrahydropyridodiazepine compounds for treating pain and pain related conditions. WO2017191304A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2143584-82-9