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Ganglioside GM2

CAT: 0804-HY-148385Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148385Size:1 mg
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Description
Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling[1][2][3].
CAS Number
127663-77-8
UNSPSC
12352005
Target
Endogenous Metabolite; ERK; FAK; Integrin; p38 MAPK; Src
Type
Natural Products
Related Pathways
Cytoskeleton; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ganglioside-gm2.html
Purity
98.0
Smiles
OC([C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)O[C@H]2[C@H]([C@H](O[C@H]([C@@H]2O)O[C@@H]3[C@H](O[C@H]([C@@H]([C@H]3O)O)OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCCCCCCCCCCCC)=O)CO)CO)O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)NC(C)=O)=O
Molecular Formula
C67H121N3O26
Molecular Weight
1384.68
References & Citations
[1]Tai T, et al. Ganglioside GM2 as a human tumor antigen (OFA-I-1) . Proc Natl Acad Sci U S A. 1983 Sep;80 (17) :5392-6.|[2]Kundu M, et al. Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathway. Biochim Biophys Acta. 2016 Jul;1863 (7 Pt A) :1472-89.|[3]Sandhoff K, et al. Gangliosides and gangliosidoses: principles of molecular and metabolic pathogenesis. J Neurosci. 2013 Jun 19;33 (25) :10195-208.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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