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Ganglioside GM3

CAT: 0804-HY-114456-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114456-01Size:1 mg
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Description
Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia[1].
CAS Number
124579-05-1
Product Name Alternative
D-APV; D-2-Amino-5-phosphonovaleric acid
UNSPSC
12352005
Target
Insulin Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ganglioside-gm3.html
Purity
99.42
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC([C@@]1(O[C@@]([C@H](NC(C)=O)[C@@H](O)C1)([H])[C@H](O)[C@H](O)CO)O[C@@H]2[C@H]([C@@H](O[C@H](CO)[C@@H]2O)O[C@]3([H])[C@H](O[C@@H](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCCCCCCCCCCCC)=O)[C@H](O)[C@H]3O)CO)O)=O
Molecular Formula
C59H108N2O21
Molecular Weight
1181.49
References & Citations
[1]Nihei W, et al. NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains. J Lipid Res. 2018 Nov;59 (11) :2181-2187.|[2]Inokuchi JI, et al. Pathophysiological Significance of GM3 Ganglioside Molecular Species With a Particular Attention to the Metabolic Syndrome Focusing on Toll-Like Receptor 4 Binding. Front Mol Biosci. 2022 May 30;9:918346.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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