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TP0556351

CAT: 0804-HY-147936Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147936Size:1 Each
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Description
TP0556351 is a potent and selective matrix metalloproteinase-2 (MMP2) inhibitor with an IC50 value of 0.2 nM. TP0556351 reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model. TP0556351 can be used for researching idiopathic pulmonary fibrosis (IPF) [1].
CAS Number
2787582-17-4
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tp0556351.html
Solubility
10 mM in DMSO
Smiles
CC(C[C@@H](C(N([C@H](C(N1CCC[C@H]1CC(N)=O)=O)CCC(O)=O)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCCNC(C2=CC=C(OC3=CC=C(C(N)=O)C=C3)C=C2)=O)=O)CCC(O)=O)=O)CC(O)=O)=O)CCN)=O)C
Molecular Formula
C50H70N10O16
Molecular Weight
1067.15
References & Citations
[1]Takeuchi T, et al. Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. J Med Chem. 2022 Jun 23;65 (12) :8493-8510.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-2

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