RNA polymerase II-IN-2

RNA polymerase II-IN-2

• CAS Number: 2891451-33-3
• UNSPSC Description: RNA polymerase II-IN-2 (compound 20iii) is a potent RNA polymerase II (Pol II) inhibitor with Ki value of 9.5 nM. RNA polymerase II-IN-2 has cytotoxicity against cancer cells, and exhibits 2 and 5 fold toxicity than α-amanitin against CHO and HEK293[1].
• Target Antigen: DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/rna-polymerase-ii-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@H](C(CC)CC)NC(CNC1=O)=O)NCC(N[C@@H]2C(N[C@H](C(N3C[C@@H](C[C@H]3C(N[C@H](C(N[C@H]1CC4=C(S[C@H]2C)NC5=C4C=CC=C5)=O)[C@H]([C@H](CO)O)C)=O)O)=O)CC(N)=O)=O)=O
• Molecular Weight: 915.02
• References & Citations: [1]Todorovic M, et al. Rationally Designed Amanitins Achieve Enhanced Cytotoxicity. J Med Chem. 2022 Jun 13.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported