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ZLWT-37

CAT: 0804-HY-147771Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147771Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZLWT-37 is a potent, orally active CDKs inhibitor with IC50 values of 0.002 μM and 0.054 μM against CDK9 and CDK2, respectively. ZLWT-37 induces apoptosis and arrests the cell cycle in the G2/M phase in HCT116 cells[1].
CAS Number
2813347-44-1
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zlwt-37.html
Solubility
10 mM in DMSO
Smiles
N[C@H]1CCN(C1)C2=C3CCCCC3=NC4=C2C=C(C=C4)C5=CC=NC(NC(C6CC6)=O)=C5.Cl
Molecular Formula
C26H30ClN5O
Molecular Weight
464.00
References & Citations
[1]Liu W, et al. Discovery of novel tacrine derivatives as potent antiproliferative agents with CDKs inhibitory property. Bioorg Chem. 2022 Sep;126:105875.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK9

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