Microtubule inhibitor 4
CAT:
804-HY-147725
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Microtubule inhibitor 4
- CAS Number: 2411962-64-4
- UNSPSC Description: Microtubule inhibitor 4 (compound 2) is a potent microtubule inhibitor. Microtubule inhibitor 4 shows cytotoxicity with IC50s of 4.0, 3.2, 2.1 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 4 shows the inhibition of tubulin polymerization[1].
- Target Antigen: Microtubule/Tubulin
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/microtubule-inhibitor-4.html
- Solubility: 10 mM in DMSO
- Smiles: CC(C)(C1=C(N=CN1)/C=C2NC(/C(NC\2=O)=C/C3=CC(OC4=CC=C(C=C4)F)=CC=C3)=O)C
- Molecular Weight: 446.47
- References & Citations: [1]Ding Z, et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28(10):115435.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported