FRα-IN-1

• UNSPSC Description:

  FRα-IN-1 (Compound 4) is a tumor-targeting agent. FRα-IN-1 shows selective anticancer activity towards folate receptors (FRα and FRβ) expression cells[1].

• Target Antigen:

  Antifolate

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/frα-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCCCC(N2)=CC3=C2N=C(N)NC3=O)C=C1)=O

• Molecular Weight:

  456.45

• References & Citations:

  [1]Golani LK, et al. Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier. Bioorg Med Chem. 2020 Jun 15;28(12):115544.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2028296-64-0