IleRS-IN-1

• Description :

  IleRS-IN-1 (compound 11) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a Ki, app of 88 nM[1].

• UNSPSC :

  12352005

• Target :

  Aminoacyl-tRNA Synthetase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/ilers-in-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@H]([C@@H]1O)[C@@H](CO[C@@H]1CO[S](NC([C@@H](N)[C@@H](C)CC)=O)(=O)=O)CCCN2C=C(C3=CC=CC=C3)N=N2

• Molecular Formula :

  C23H35N5O7S

• Molecular Weight :

  525.62

• References & Citations :

  [1]De Ruysscher D, et al. Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase. Bioorg Med Chem. 2020 Aug 1;28 (15) :115580.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2502167-19-1]