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IleRS-IN-1

CAT: 0804-HY-147672Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147672Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IleRS-IN-1 (compound 11) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a Ki, app of 88 nM[1].
CAS Number
2502167-19-1
UNSPSC
12352005
Target
Aminoacyl-tRNA Synthetase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ilers-in-1.html
Solubility
10 mM in DMSO
Smiles
O[C@H]([C@@H]1O)[C@@H](CO[C@@H]1CO[S](NC([C@@H](N)[C@@H](C)CC)=O)(=O)=O)CCCN2C=C(C3=CC=CC=C3)N=N2
Molecular Formula
C23H35N5O7S
Molecular Weight
525.62
References & Citations
[1]De Ruysscher D, et al. Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase. Bioorg Med Chem. 2020 Aug 1;28 (15) :115580.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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