IleRS-IN-1

IleRS-IN-1

• CAS Number: 2502167-19-1
• UNSPSC Description: IleRS-IN-1 (compound 11) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a Ki,app of 88 nM[1].
• Target Antigen: Aminoacyl-tRNA Synthetase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/ilers-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@H]([C@@H]1O)[C@@H](CO[C@@H]1CO[S](NC([C@@H](N)[C@@H](C)CC)=O)(=O)=O)CCCN2C=C(C3=CC=CC=C3)N=N2
• Molecular Weight: 525.62
• References & Citations: [1]De Ruysscher D, et al. Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase. Bioorg Med Chem. 2020 Aug 1;28(15):115580.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported