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TPB15

CAT: 0804-HY-147670Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147670Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1) . TPB15 shows good anti-tumor activity with low toxicity[1].
CAS Number
2170347-69-8
UNSPSC
12352005
Target
Apoptosis; Gli; Hedgehog; Smo
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tpb15.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(N=C(C=C1)Cl)Cl)NC2=CC(C3=NN=C4C(Cl)=CC=CN43)=C(C=C2)Cl
Molecular Formula
C18H9Cl4N5O
Molecular Weight
453.11
References & Citations
[1]Tian N, et al. Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo. Bioorg Med Chem. 2020 Aug 15;28 (16) :115584.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19185812-01TPB15

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