Pyronaridine-d4 (tetraphosphate)

Pyronaridine-d4 (tetraphosphate)

• CAS Number: 1186026-25-4
• UNSPSC Description: Pyronaridine-d4 (tetraphosphate) is the deuterium labeled Pyronaridine tetraphosphate[1]. Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[2][3].
• Target Antigen: Parasite
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Purity: 97.00
• Solubility: H2O : 25 mg/mL (ultrasonic;warming)
• Smiles: O=P(O)(O)O.ClC1=CC2=C(C=C1)C(NC3=CC(C([2H])([2H])N4CCCC4)=C(C(C([2H])([2H])N5CCCC5)=C3)O)=C6C(C=CC(OC)=N6)=N2.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O
• Molecular Weight: 914.06
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Vivas L, et al. Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo. Acta Trop. 2008 Mar;105(3):222-8.|[3]Jun Li, et al. Old drug repurposing for neglected disease: Pyronaridine as a promising candidate for the treatment of Echinococcus granulosus infections. EBioMedicine. 2020 Apr;54:102711.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported