CEP-8983

• Description :

  CEP-8983 is a PARP-1 and PARP-2 inhibitor (IC50: 20 and 6 nM) . CEP-8983 is an effective chemosensitizing agent, and can sensitize chemotherapy-resistant cell lines and subcutaneous xenografts to Temozolomide (HY-17364) and Camptothecin (HY-16560) [1].

• CAS Number :

  [374071-46-2]

• UNSPSC :

  12352005

• Target :

  PARP

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cep-8983.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=CC=CC2=C1C3=C(C(NC4=O)=O)C4=C(CCC5)C5=C3N2

• Molecular Formula :

  C18H14N2O3

• Molecular Weight :

  306.32

• References & Citations :

  [1]Miknyoczki S, et al. The selective poly (ADP-ribose) polymerase-1 (2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity. Mol Cancer Ther. 2007 Aug;6 (8) :2290-302.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported