Products for Research Use Only
RegisterLogin

CEP-8983

CAT: 0804-HY-14688Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-14688Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CEP-8983 is a PARP-1 and PARP-2 inhibitor (IC50: 20 and 6 nM). CEP-8983 is an effective chemosensitizing agent, and can sensitize chemotherapy-resistant cell lines and subcutaneous xenografts to Temozolomide and Camptothecin (HY-16560).
CAS Number
374071-46-2
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cep-8983.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=CC2=C1C3=C(C(NC4=O)=O)C4=C(CCC5)C5=C3N2
Molecular Formula
C18H14N2O3
Molecular Weight
306.32
References & Citations
[1]Miknyoczki S, et al. The selective poly (ADP-ribose) polymerase-1 (2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity. Mol Cancer Ther. 2007 Aug;6 (8) :2290-302.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-15343-01CEP-33779
HY-14243CEP-14083
HY-16135-01CEP-11981
HY-117909-01CEP-40125
HY-10412CEP-1347
HY-123172CEP-2563
HY-100946-01CEP-40783
HY-P991435CEP-37248
HY-13590CEP-7055
HY-18030CEP-28122

Alternative Products

CatalogName
T26979-01CEP-8983
8108/5CEP
C4025-25CEP-28122
B3271-5CEP-37440
BA8880-10CEP-40783
A1413-5CEP-32496
A4146-5.1CEP-33779
T9901A-1645-01CEP-37248
T68537-01CEP-14513
MBS130077-01CEP 33779

Popular Products