Products for Research Use Only
RegisterLogin

CEP-7055

CAT: 0804-HY-13590Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13590Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CEP-7055 (compound 21) is a novel vascular endothelial growth factor R2 (VEGF-R2) tyrosine kinase inhibitor with potent inhibitory activity. Studies have found that the inhibitor activity can be significantly improved by optimizing the R9 substituent. Compound 21 has potent low nanomolar inhibition of human VEGF-R tyrosine kinase and shows good selectivity against multiple tyrosine and serine/threonine kinases. N, N-dimethylglycine ester 40 was prepared to improve its water solubility and oral bioavailability. In animal pharmacokinetic studies, a significant increase in the plasma level of 21 was observed after oral administration of 40. Compound 21 showed significant in vivo antitumor activity in multiple tumor models and has entered phase I clinical trials as a water-soluble N, N-dimethylglycine ester proagent of 40 (CEP-7055) .
CAS Number
402857-58-3
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cep-7055.html
Smiles
O=C(OCCCN1C2=C(C3=C1C=CC(COC(C)C)=C3)C4=C(C(NC4)=O)C5=C2CC6=C5C=CC=C6)CN(C)C
Molecular Formula
C32H35N3O4
Molecular Weight
525.64
References & Citations
[1]A New Class of Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Structure-Activity Relationships for a Series of 9-Alkoxymethyl-12- (3-hydroxypropyl) indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the Identification of CEP-5214 and Its Dimethylglycine Ester Prodrug Clinical Candidate CEP-7055
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-117909-01CEP-40125
HY-16135-01CEP-11981
HY-14243CEP-14083
HY-10412CEP-1347
HY-15343-01CEP-33779
HY-123172CEP-2563
HY-100946-01CEP-40783
HY-P991435CEP-37248
HY-18030CEP-28122
HY-15841-01CEP-37440

Alternative Products

CatalogName
MBS5811838CEP-7055
8108/5CEP
2332323WSE-7055 EzRun TG
C4025-25CEP-28122
B3271-5CEP-37440
BA8880-10CEP-40783
A1413-5CEP-32496
A4146-5.1CEP-33779
T9901A-1645-01CEP-37248
T68537-01CEP-14513

Popular Products