PAK1-IN-1

CAT: 0804-HY-146681Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-146681Size:1 Each

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Description

PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner[1].

CAS Number

2485732-30-5

UNSPSC

12352005

Target

PAK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pak1-in-1.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=CN(C1=O)C2=CC=C(C(Cl)=C2)C3=CC=C4C(NN=C4C(NCC5=CC=NC=C5)=O)=C3

Molecular Formula

C26H20ClN5O2

Molecular Weight

469.92

References & Citations

[1]Zhang M, et al. Design and synthesis of 1H-indazole-3-carboxamide derivatives as potent and selective PAK1 inhibitors with anti-tumour migration and invasion activities. Eur J Med Chem. 2020 Oct 1;203:112517.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PAK1; PAK4

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