Fluvastatin (sodium monohydrate)

Fluvastatin (sodium monohydrate)

• CAS Number: 201541-53-9
• UNSPSC Description: Fluvastatin (XU 62-320) sodium monohydrate is a first fully synthetic, competitive HMG-CoA reductaseinhibitor with an IC50 of 8 nM. Fluvastatin (sodium monohydrate) protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2].
• Target Antigen: Apoptosis; HMG-CoA Reductase (HMGCR)
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/fluvastatin-sodium-monohydrate.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(O[Na])C[C@@H](O)C[C@@H](O)/C=C/C1=C(C2=CC=C(C=C2)F)C3=CC=CC=C3N1C(C)C.O
• Molecular Weight: 451.46
• References & Citations: [1]Makabe S, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010;213(2):377-384.|[2]Zhang W, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. Indian J Exp Biol. 2010;48(12):1167-1174.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 4