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Fluvastatin (sodium monohydrate)

CAT: 0804-HY-14664DSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14664DSize:1 Each
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Description
Fluvastatin (XU 62-320) sodium monohydrate is a first fully synthetic, competitive HMG-CoA reductaseinhibitor with an IC50 of 8 nM. Fluvastatin (sodium monohydrate) protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2].
CAS Number
201541-53-9
Product Name Alternative
XU 62-320 (monohydrate)
UNSPSC
12352005
Target
Apoptosis; HMG-CoA Reductase (HMGCR)
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fluvastatin-sodium-monohydrate.html
Solubility
10 mM in DMSO
Smiles
O=C(O[Na])C[C@@H](O)C[C@@H](O)/C=C/C1=C(C2=CC=C(C=C2)F)C3=CC=CC=C3N1C(C)C.O
Molecular Formula
C24H27FNNaO5
Molecular Weight
451.46
References & Citations
[1]Makabe S, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010;213 (2) :377-384.|[2]Zhang W, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. Indian J Exp Biol. 2010;48 (12) :1167-1174.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4

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