Fluvastatin (sodium)

Fluvastatin (sodium)

• CAS Number: 93957-55-2
• UNSPSC Description: Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2][3].
• Target Antigen: Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR)
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Cardiovascular Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/Fluvastatin-sodium.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
• Smiles: O=C(O[Na])C[C@H](O)C[C@H](O)/C=C/C(N1C(C)C)=C(C2=CC=C(F)C=C2)C3=C1C=CC=C3
• Molecular Weight: 433.45
• References & Citations: [1]Makabe S, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84.|[2]Wu Zhang, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. Indian J Exp Biol. 2010 Dec;48(12):1167-74.Front Bioeng Biotechnol. 2022 Mar 17;10:826093.|Mol Med Rep. 2018 Mar;17(3):3944-3950.|Pathogens. 2021, 10(3), 283.|Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.|Biomed Pharmacother. 2024 Apr 30:175:116644.|bioRxiv. 2024 October 04.|Cell Prolif. 2021 Jan;54(1):e12953.|Cell Rep Med. 2024 May 29:101592.|Chem Eng J. 1 January 2023, 138972.|Front Cell Dev Biol. 2020 May 28;8:404.|Front Oncol. 10 May 2021.|Front Oncol. 2021 May 10;11:595285.|Pharmacol Res. 2023 Mar 10;106724.|PLoS Biol.2024 May 28;22(5):e3002621.|Proteomics. 2023 May 4;e2300041.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched