Aspirin-d4

Aspirin-d4

• CAS Number: 97781-16-3
• UNSPSC Description: Aspirin-d4 is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL[1][2].
• Target Antigen: Autophagy; COX; Mitophagy; Virus Protease
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Autophagy;Immunology/Inflammation
• Field of Research: Inflammation/Immunology; Cancer
• Purity: 98.08
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: OC(C1=C(C([2H])=C([2H])C([2H])=C1[2H])OC(C)=O)=O
• Molecular Weight: 184.18
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and induciblecyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7.|[3]Vane JR, et al. The mechanism of action of aspirin. Thromb Res. 2003 Jun 15;110(5-6):255-8.|[4]Wu KK, et al. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Semin Vasc Med. 2003 May;3(2):107-12.|[5]Kopp E, et al. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994 Aug 12;265(5174):956-9.|[6]Blanco FJ, et al. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366-73.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported