Aspirin-d3
CAT:
804-HY-14654S-01
Size:
100 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Aspirin-d3
- CAS Number: 921943-73-9
- UNSPSC Description: Aspirin-d3 is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL.
- Target Antigen: Autophagy; COX; Mitophagy; Virus Protease
- Type: Isotope-Labeled Compounds
- Related Pathways: Anti-infection;Autophagy;Immunology/Inflammation
- Field of Research: Inflammation/Immunology; Cancer
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(O)C1=CC=CC=C1OC(C([2H])([2H])[2H])=O
- Molecular Weight: 183.18
- References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and induciblecyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7.;Vane JR, et al. The mechanism of action of aspirin. Thromb Res. 2003 Jun 15;110(5-6):255-8.;Wu KK, et al. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Semin Vasc Med. 2003 May;3(2):107-12.;Kopp E, et al. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994 Aug 12;265(5174):956-9.;Blanco FJ, et al. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366-73.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported