Products for Research Use Only
RegisterLogin

Amsilarotene

CAT: 0804-HY-14653-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-14653-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with Ki of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer[1][2][3].
CAS Number
125973-56-0
Product Name Alternative
TAC-101; Am 555S
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Apoptosis; RAR/RXR
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amsilarotene.html
Concentration
10mM
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[Si](C)(C)C1=CC(C(NC2=CC=C(C(O)=O)C=C2)=O)=CC([Si](C)(C)C)=C1
Molecular Formula
C20H27NO3Si2
Molecular Weight
385.60
Precautions
H315, H319
References & Citations
[1]Sun SY, et al. Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells. Cancer Res. 1997 Nov 1;57 (21) :4931-9.|[2]Suzuki N, et al. A novel retinoid, 4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid (TAC-101), induces apoptosis of human ovarian carcinoma cells and shows potential as a new antitumor agent for clear cell adenocarcinoma. Gynecol Oncol. 2004 Sep;94 (3) :643-9.|[3]Fujimoto K, et al. Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cells. Int J Cancer. 1999 May 17;81 (4) :637-44.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
BA3140-5.1Amsilarotene
MBS387625-01Amsilarotene (TAC-101)
A13122-50Amsilarotene (TAC-101) 50mg
A13122-5Amsilarotene (TAC-101) 5mg
A13122-200Amsilarotene (TAC-101) 200mg
A13122-2Amsilarotene (TAC-101) 2mg
A13122-1Amsilarotene (TAC-101) 1mg
A13122-100Amsilarotene (TAC-101) 100mg
A13122-25Amsilarotene (TAC-101) 25mg
A13122-10Amsilarotene (TAC-101) 10mg

Popular Products