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NusB-IN-1

CAT: 0804-HY-146463Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146463Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NusB-IN-1 (Compound 22r) is a potent, orally active bacterial rRNA synthesis inhibitor. NusB-IN-1 shows antimicrobial activity against MRSA and VRSA[1]. NusB-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
2923738-92-3
UNSPSC
12352005
Target
Bacterial; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nusb-in-1.html
Solubility
10 mM in DMSO
Smiles
O=[N+](C1=CC(CNC2=C(C=CC=C2)C#CC3=CC=CC=C3)=C(C=C1)O)[O-]
Molecular Formula
C21H16N2O3
Molecular Weight
344.36
References & Citations
[1]Qiu Y, et al. Synthesis and biological evaluation of nusbiarylin derivatives as bacterial rRNA synthesis inhibitor with potent antimicrobial activity against MRSA and VRSA. Bioorg Chem. 2022 Jul;124:105863.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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