GRP78-IN-2

CAT: 0804-HY-146420Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-146420Size:1 Each
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Description
GRP78-IN-2 (Compound FL5) is a GRP78 (Glucose Regulated Protein 78 kDa) inhibitor. GRP78-IN-2 preferentially targeting cell surface GRP78 and shows potent antiangiogenic and anticancer activities without affecting other normal cells[1].
CAS Number
[1882875-63-9]
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/grp78-in-2.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(OC)=CC(C(OCC2=CC=C(C=C2)C3=C(C4=CC=CC=C4O3)C(NCC(C)C)=O)=O)=C1
Molecular Formula
C29H29NO6
Molecular Weight
487.54
References & Citations
[1]Qiao Y, et al. Discovery of small molecules targeting GRP78 for antiangiogenic and anticancer therapy. Eur J Med Chem. 2020 May 1;193:112228.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP70

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