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BET-IN-8

CAT: 0804-HY-146292Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146292Size:1 Each
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Description
BET-IN-8 (Compound 27) is a potent inhibitor of BET with a Ki and Kd of 0.83 and 0.571 μM, respectively. BET-IN-8 ameliorates LPS-induced sepsis in vivo. BET-IN-8 has the potential for the research of sepsis[1].
CAS Number
2769893-19-6
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/bet-in-8.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(C2=C(C(NC(SCC3=CC=CC=C3C)=N2)=O)C#N)=CC(OC)=C1OC
Molecular Formula
C22H21N3O4S
Molecular Weight
423.48
References & Citations
[1]Chen X, et al. Discovery of 2- ((2-methylbenzyl) thio) -6-oxo-4- (3,4,5-trimethoxyphenyl) -1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis. Eur J Med Chem. 2022 May 8;238:114423
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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