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TRPC4/5-IN-3

CAT: 0931-T205276-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205276-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3053390-98-7
Target
TRP/TRPV Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
TRPC4/5-IN-3 (Compound 32) is an orally active inhibitor of transient receptor potential canonical channels 4 and 5 (TRPC4/5), with IC50 values of 3.6 nM and 5.5 nM, respectively. It inhibits the hERG channel with an IC50 of 6.5 μM. This compound demonstrates good metabolic stability in human, rat, and mouse liver microsomes. In mouse models, TRPC4/5-IN-3 exhibits antidepressant and anxiolytic effects and displays favorable pharmacokinetic properties, with an oral bioavailability of 87%.
Smiles
O=C1C2=C(N=C(N2CC3=CC=C(F)C=C3F)C4(F)CCC(F)(F)CC4)N(C(=O)N1CCCO)C
Molecular Formula
C22H23F5N4O3
Molecular Weight
486.435
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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