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NS5A-IN-4

CAT: 0804-HY-146126Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-146126Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NS5A-IN-4 (Compound 1.12) is an orally active pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with IC50 values of 1.2, 2296, 4.6, 362, 10.3 and 693 pM against gT1b, gT1a, gT2a, gT3a, gT4a and gT5a[1]. NS5A-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[2088243-03-0]
UNSPSC
12352005
Target
HCV Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ns5a-in-4.html
Solubility
10 mM in DMSO
Smiles
COC(N[C@@H](C(C)C)C(N1[C@H](C2=NC=C(C3=CC(C4=CC=CC=C4)=C(C=C3)C#CC#CC5=CN=C([C@H]6N(CCC6)C([C@@H](C7=CC=CC=C7)NC(OC)=O)=O)N5)N2)CCC1)=O)=O
Molecular Formula
C47H48N8O6
Molecular Weight
820.93
References & Citations
[1]Ivashchenko AA, et al. Synthesis, biological evaluation and in silico modeling of novel pan-genotypic NS5A inhibitors. Bioorg Med Chem. 2020 Oct 15;28 (20) :115716.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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