NS5A-IN-4

• Description:

  NS5A-IN-4 (Compound 1.12) is an orally active pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with IC50 values of 1.2, 2296, 4.6, 362, 10.3 and 693 pM against gT1b, gT1a, gT2a, gT3a, gT4a and gT5a[1]. NS5A-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC:

  12352005

• Target:

  HCV Protease

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/ns5a-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC (N[C@@H] (C (C) C) C (N1[C@H] (C2=NC=C (C3=CC (C4=CC=CC=C4) =C (C=C3) C#CC#CC5=CN=C ([C@H]6N (CCC6) C ([C@@H] (C7=CC=CC=C7) NC (OC) =O) =O) N5) N2) CCC1) =O) =O

• Molecular Formula:

  C47H48N8O6

• Molecular Weight:

  820.93

• References & Citations:

  [1]Ivashchenko AA, et al. Synthesis, biological evaluation and in silico modeling of novel pan-genotypic NS5A inhibitors. Bioorg Med Chem. 2020 Oct 15;28 (20) :115716.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2088243-03-0