Products for Research Use Only
RegisterLogin

IRAK4-IN-15

CAT: 0804-HY-146113Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-146113Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC50 of 0.002 μM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. [1].
CAS Number
2667681-85-6
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/irak4-in-15.html
Solubility
10 mM in DMSO
Smiles
CC1=NC=C(C2=NC3=C(NC(C)C)N=C(NC4=CN(C(C5)CC65CN(C)C6)N=C4)N=C3C=C2F)C=N1
Molecular Formula
C25H29FN10
Molecular Weight
488.56
References & Citations
[1]Degorce SL, et al. Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors. Bioorg Med Chem. 2020 Dec 1;28 (23) :115815.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4

Related Products

CatalogName
HY-174843IRAK4-IN-32
HY-151365-01IRAK4-IN-22
HY-146112-01IRAK4-IN-14
HY-109585-01IRAK4-IN-7
HY-151363-01IRAK4-IN-21
HY-155518IRAK4-IN-25
HY-150732IRAK4-IN-18
HY-114181-01IRAK4-IN-4
HY-172372IRAK4-IN-30
HY-146072IRAK4-IN-11

Alternative Products

CatalogName
T63262-01IRAK4-IN-15
1578IRAK4 Adenovirus (Ad-IRAK4)
483657IRAK4
70R-11925IRAK4 antibody
BA6065-10IRAK4-IN-14
BA6057-50IRAK4-IN-1
BA6061-1IRAK4-IN-21
BA6067-1IRAK4-IN-20
BA6062-10IRAK4-IN-6
T78744-01IRAK4-IN-24

Popular Products