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RMS3

CAT: 0804-HY-146096Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146096Size:1 Each
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Description
RMS3, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS3 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS3 has strong anticancer property[1].
CAS Number
2497686-66-3
UNSPSC
12352005
Target
Apoptosis; P-glycoprotein
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rms3.html
Solubility
10 mM in DMSO
Smiles
COC1=C2C3=C(C=C1OC)CCN(C)[C@@]3([H])CC4=CC=C(OC(F)(F)F)C(OC5=CC=C(C[C@]6([H])C7=CC(O2)=C(C=C7CCN6C)OC)C=C5)=C4
Molecular Formula
C38H39F3N2O6
Molecular Weight
676.72
References & Citations
[1]RamonaSchütz, et al. Synthesis, biological evaluation and toxicity of novel tetrandrine analogues. Eur J Med Chem. 2020 Dec 1;207:112810.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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