IRAK4-IN-12

CAT: 0804-HY-146073Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-146073Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

IRAK4-IN-12 (compound 37) is a potent IRAK4 inhibitor with an IC50 of 0.015 µM. IRAK4-IN-12 shows cell pIRAK4 potencies with an IC50 of 0.5 µM[1].

UNSPSC

12352005

Target

IRAK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/irak4-in-12.html

Solubility

10 mM in DMSO

Smiles

F[C@@H](CN1C=CC2=C(C(NC3(CC3)C)=NC(NC4=CN(N=C4)C5CC6(CN(C6)C)C5)=N2)C1=O)C

Molecular Formula

C24H31FN8O

Molecular Weight

466.55

References & Citations

[1]Cumming IA, et al. Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors. Bioorg Med Chem. 2022 Jun 1;63:116729.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IRAK4

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