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M7GpppGpG

CAT: 0804-HY-145976Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145976Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M7GpppGpG, an oligonucleotide, is an M7GpppNpG trinucleotide cap analogue. m7GpppGpG prevents premature degradation by 5′-exonucleases and recruits proteins required for pre-mRNA splicing, mRNA transport and initiation of protein biosynthesis[1].
CAS Number
133608-76-1
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/m7gpppgpg.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(OC[C@@H]1[C@@H](OP(O)(OC[C@H]2O[C@@H](N3C(NC(N)=NC4=O)=C4N=C3)[C@H](O)[C@@H]2O)=O)[C@@H](O)[C@H](N5C(NC(N)=NC6=O)=C6N=C5)O1)OP(OP(OC[C@H]7O[C@@H](N8C(NC(N)=N9)=C([N+](C)=C8)C9=O)[C@H](O)[C@@H]7O)([O-])=O)(O)=O
Molecular Formula
C31H41N15O25P4
Molecular Weight
1147.64
References & Citations
[1]Sikorski PJ, et, al. The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells. Nucleic Acids Res. 2020 Feb 28;48 (4) :1607-1626.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

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