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Amidate-VC-PAB-MMAF

CAT: 0804-HY-145951Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145951Size:1 Each
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Description
Amidate-VC-PAB-MMAF consists a cleavable ADC linker (Amidate-VC-PAB) and a potent tubulin polymerization inhibitor (MMAF) . Amidate-VC-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs) . Amidate-VC-PAB-MMAF reduces off-target cytotoxicity of ADCs[1].
CAS Number
2202782-90-7
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amidate-vc-pab-mmaf.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O)[C@H]([C@@](CCC2)([H])N2C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(C(C=C4)=CC=C4N[P](OCC)(C#C)=O)=O)=O)=O)=O)=O)=O)=O)OC
Molecular Formula
C69H102N11O16P
Molecular Weight
1372.59
References & Citations
[1]Nareshkumar Jain, et al. Current ADC Linker Chemistry. Pharm Res. 2015 Nov;32 (11) :3526-40.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported

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