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Chalcones A-N-5

CAT: 0804-HY-145858Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145858Size:1 Each
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Description
Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesn’t show cytotoxicity at the concentration lower than 100 µM (with IC50 > 1 mM), but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by Aβ1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD[1].
CAS Number
2756846-09-8
UNSPSC
12352005
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chalcones-a-n-5.html
Solubility
10 mM in DMSO
Smiles
CN(C1=NC=C(C=N1)NC2=CC=C(C=C2)/C=C/C(C3=C(C(O)=C(C=C3)O)O)=O)C
Molecular Formula
C21H20N4O4
Molecular Weight
392.41
References & Citations
[1]Liu Y, et al. Rational design, synthesis and activities of hydroxylated chalcones as highly potent dual functional agents against Alzheimer's disease. Bioorg Chem. 2022;122:105662.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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