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Chalcones A-N-5

CAT: 0931-T74461-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74461-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2756846-09-8
Target
Others, Ferroptosis
Related Pathways
Apoptosis, Others
Bioactivity
Chalcones A-N-5, a trihydroxy chalcone derivative, exhibits no cytotoxicity at concentrations below 100 μM (with IC 50 > 1 mM) and notably enhances cell proliferation. It is particularly effective in encouraging neuronal cell growth within damaged brain tissue and demonstrates an ability to inhibit ferroptosis triggered by RSL or erastin, while also reducing lipid peroxidation levels associated with Aβ1-42 protein aggregation. Given these properties, Chalcones A-N-5 represents a promising molecular framework for further development as a lead compound in in vivo studies aimed at researching Alzheimer's Disease (AD) [1].
Smiles
CN(C)c1ncc(Nc2ccc(\C=C\C(=O)c3ccc(O)c(O)c3O)cc2)cn1
Molecular Formula
C21H20N4O4
Molecular Weight
392.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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