cis,trans-Germacrone

cis,trans-Germacrone

• CAS Number: 32663-51-7
• UNSPSC Description: cis,trans-Germacrone is a isomer of Germacrone (HY-N0440). Germacrone exhibits a wide range of antitumor, antioxidant and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters the Akt/MDM2/p53. Germacrone also arrests cell cycle at G1/S phase[1].
• Target Antigen: Akt; MDM-2/p53
• Type: Reference compound
• Related Pathways: Apoptosis;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cis-trans-germacrone.html
• Solubility: 10 mM in DMSO
• Smiles: C/C(C)=C1C(C/C(C)=C\CC/C(C)=C/C\1)=O
• Molecular Weight: 218.33
• References & Citations: [1]Zhao Y, et al. Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway. Mol Med Rep. 2021 Jun;23(6):452.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported