Cis, trans-Germacrone

• Description:

  Cis, trans-Germacrone is a isomer of Germacrone (HY-N0440) . Germacrone exhibits a wide range of antitumor, antioxidant and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters the Akt/MDM2/p53. Germacrone also arrests cell cycle at G1/S phase[1].

• UNSPSC:

  12352211

• Target:

  Akt; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cis-trans-germacrone.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C/C(C)=C1C(C/C(C)=C\CC/C(C)=C/C\1)=O

• Molecular Formula:

  C15H22O

• Molecular Weight:

  218.33

• References & Citations:

  [1]Zhao Y, et al. Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway. Mol Med Rep. 2021 Jun;23 (6) :452.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [32663-51-7]