Germacrone

• Description:

  Germacrone is a sesquiterpene compound with multiple biological activities. Germacrone inhibits the H1N1 and H3N2 influenza A virus and the influenza B virus. Germacrone blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone inhibits 5α-reductase and has anti-androgenic effect. Germacrone has neuroprotective functions and can be used for the study of traumatic brain injury (TBI) . Germacrone also has antioxidant activity[1][2][3][4][5].

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H335

• Target:

  5 alpha Reductase; Apoptosis; Influenza Virus; Keap1-Nrf2; Lactate Dehydrogenase; NF-κB

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Metabolic Enzyme/Protease; NF-κB

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection; Endocrinology; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/germacrone.html

• Purity:

  99.76

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1C/C(C)=C/CC/C(C)=C/C/C1=C(C)\C

• Molecular Formula:

  C15H22O

• Molecular Weight:

  218.33

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Liao Q, et al. Germacrone inhibits early stages of influenza virus infection. Antiviral Res. 2013 Dec;100 (3) :578-88.|[2]Zhong Z, et al. Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis. Eur J Pharmacol. 2011 Sep 30;667 (1-3) :50-5.|[3]Wang Z, et al. Germacrone alleviates collagen-induced arthritis via regulating Th1/Th2 balance and NF-κB activation. Biochem Biophys Res Commun. 2019 Oct 20;518 (3) :560-564.|[4]Zhuang S, et al. Germacrone alleviates neurological deficits following traumatic brain injury by modulating neuroinflammation and oxidative stress. BMC Complement Med Ther. 2021 Jan 5;21 (1) :6.|[5]Suphrom N, et al. Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb. Fitoterapia. 2012 Jul;83 (5) :864-71.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [6902-91-6]