Germacrone

CAT: 0804-HY-N0440-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0440-01Size:1 mg
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Description
Germacrone is a sesquiterpene compound with multiple biological activities. Germacrone inhibits the H1N1 and H3N2 influenza A virus and the influenza B virus. Germacrone blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone inhibits 5α-reductase and has anti-androgenic effect. Germacrone has neuroprotective functions and can be used for the study of traumatic brain injury (TBI) . Germacrone also has antioxidant activity[1][2][3][4][5].
CAS Number
[6902-91-6]
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
5 alpha Reductase; Apoptosis; Influenza Virus; Keap1-Nrf2; Lactate Dehydrogenase; NF-κB
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Endocrinology; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/germacrone.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C/C(C)=C/CC/C(C)=C/C/C1=C(C)\C
Molecular Formula
C15H22O
Molecular Weight
218.33
Precautions
H315, H319, H335
References & Citations
[1]Liao Q, et al. Germacrone inhibits early stages of influenza virus infection. Antiviral Res. 2013 Dec;100 (3) :578-88.|[2]Zhong Z, et al. Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis. Eur J Pharmacol. 2011 Sep 30;667 (1-3) :50-5.|[3]Wang Z, et al. Germacrone alleviates collagen-induced arthritis via regulating Th1/Th2 balance and NF-κB activation. Biochem Biophys Res Commun. 2019 Oct 20;518 (3) :560-564.|[4]Zhuang S, et al. Germacrone alleviates neurological deficits following traumatic brain injury by modulating neuroinflammation and oxidative stress. BMC Complement Med Ther. 2021 Jan 5;21 (1) :6.|[5]Suphrom N, et al. Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb. Fitoterapia. 2012 Jul;83 (5) :864-71.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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