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Pozanicline

CAT: 0804-HY-14565Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14565Size:1 Each
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Description
Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM. Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction[1].
CAS Number
161417-03-4
Product Name Alternative
ABT-089
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pozanicline.html
Solubility
10 mM in DMSO
Smiles
CC1=C(OC[C@H]2NCCC2)C=CC=N1
Molecular Formula
C11H16N2O
Molecular Weight
192.26
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Sullivan JP, et al. ABT-089 [2-methyl-3- (2- (S) -pyrrolidinylmethoxy) pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J Pharmacol Exp Ther. 1997 Oct;283 (1) :235-46.|[2]Yildirim E, et al. ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice. Behav Pharmacol. 2015 Apr;26 (3) :241-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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