Tri-GalNAc-NHS ester

CAT: 0804-HY-145368Size: InquireDry Ice: NoHazardous: No
CAT#:0804-HY-145368Size:Inquire
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CAS Number
[1953146-83-2]
UNSPSC Description
Tri-GalNAc-NHS ester is a LYsosome TArgeting Chimera (LYTAC) and a ligand of asialoglycoprotein receptor (ASGPR). ASGPR is a lysosomal targeting receptor specifically expressed on liver cells, for the degradation of extracellular proteins including membrane proteins. Tri-GalNAc-NHS ester can be used as a protein degrader and it can be used for the research of LYTAC[1].
Target Antigen
Ligands for Target Protein for PROTAC; LYTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tri-galnac-nhs-ester.html
Solubility
10 mM in DMSO
Smiles
O=C(CCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)NC(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]2CO)[C@@H]([C@H]([C@H]2O)O)NC(C)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]3CO)[C@@H]([C@H]([C@H]3O)O)NC(C)=O)=O)=O)COCCC(NCCCNC(CCCCO[C@H](O[C@@H]4CO)[C@@H]([C@H]([C@H]4O)O)NC(C)=O)=O)=O
Molecular Weight
1832.98
References & Citations
[1]Zhou Y, et al. Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins. ACS Cent Sci. 2021 Mar 24;7(3):499-506.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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