Tri-GalNAc-NHS ester

• Target:

  LYTACs

• Related Pathways:

  PROTAC

• Bioactivity:

  Tri-GalNAc-NHS ester, a LYsosome TArgeting Chimera (LYTAC) and ligand for the asialoglycoprotein receptor (ASGPR), facilitates the degradation of extracellular proteins, including membrane proteins, via the lysosomal targeting receptor expressed on liver cells. This compound is utilized as a protein degrader in LYTAC research [1].

• Smiles:

  C(NC(CCOCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@H]2[C@H](NC(C)=O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)=O)=O)(COCCC(NCCCNC(CCCCO[C@H]3[C@H](NC(C)=O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)=O)=O)COCCC(NCCCNC(CCCCO[C@H]4[C@H](NC(C)=O)[C@@H](O)[C@@H](O)[C@@H](CO)O4)=O)=O

• Molecular Formula:

  C79H137N11O37

• Molecular Weight:

  1832.98

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1953146-83-2