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SARS-CoV-2-IN-10

CAT: 0804-HY-145276Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145276Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals[1].
CAS Number
2722634-95-7
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sars-cov-2-in-10.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1)[C@@H]1C[C@@H](C=O)NC([C@H](CC(C)C)NC(OC(C2=CC=CC=C2)C3CCC(F)(CC3)F)=O)=O
Molecular Formula
C27H37F2N3O5
Molecular Weight
521.60
References & Citations
[1]Dampalla CS, et al. Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies. J Med Chem. 2021;64 (24) :17846-17865.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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