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AM8936

CAT: 0804-HY-144827Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144827Size:1 Each
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Description
AM8936 acts as a balanced and potent cannabinoid receptor type-1 (CB1) agonist in functional assays (EC50s of 8.6 and 1.4 nM for rCB1 and hCB1, respectively) . AM8936 exhibits high affinity for rat CB1 (rCB1) with Ki of 0.55 nM. AM8936 is a potent and efficacious CB1 agonist in vivo. AM8936 can be used for the research of CNS and metabolic disorders, pain, glaucoma, etc[1].
CAS Number
2820337-96-8
UNSPSC
12352005
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/am8936.html
Solubility
10 mM in DMSO
Smiles
CC1(OC2=C([C@@H]3CC(CC[C@H]31)=O)C(O)=CC(C4(CCC4)CCCCCC#N)=C2)C
Molecular Formula
C25H33NO3
Molecular Weight
395.53
References & Citations
[1]Ioannis P Papanastasiou, et al. Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists. Eur J Med Chem. 2022 Feb 15;230:114027.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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